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KMID : 0903520060490040343
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 4 p.343 ~ p.348
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Immunostimulating and Anticancer Activities of Hot Water Extract from Capsosiphon fulvescens
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Park Hee-Yeon
Lim Chi-Won
Kim Yeon-Kye
Yoon Ho-Dong
Lee Ka-Jung
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Abstract
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To investigate the immunostimulating and anticancer activities from hot water extract of Capsosiphon fulvescens, tumor cell toxicity, sarcoma-180 growth inhibition activity, complement systemactivity, intestinal immune system and oral toxicity were performed. The extract of Capsosiphon fulvescens was prepared by hot water and precipitated by using ethanol. Partially purified extract (CFE) was obtained after dialysis and ultrafiltration. The polysaccharide compositions consisted of xylose (19.1%), fucose (15.3%), mannose (4.2%) and galactose (7.9%). The tumor cell toxicity of CFE slightly showed at high concentrations of 10-30 μg/ml, but inhibition ratio against mouse solid tumor was more increased for CFE of 40.1-59.4% than the control. Blood leukocyte counts increased to a maximum of 83% including liver, spleen and thymic of mouse. Immunoglobulin A binding amounts showed a high level of CFE of 2,454 ± 113.8-2,670 ± 133.1 μg/mg in comparison with the control of 2,092 ± 123.0 μg/mg. Acute toxicity of CFE was not detected at the concentration of 2,000 mg/kg in normal mouse.
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KEYWORD
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immunostimulating activity, anticancer activity, capsosiphon fulvescens
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